PI3K/AKT   signaling

PRKCE;ITGAM;ITGA5;IRAK1;PRKAA2;EIF2AK2;PTEN;EIF4E;PRKCZ;GRK6;MAPK1;TSC1;PLK1;

AKT2;IKBKB;PIK3CA;CDK8;CDKN1B;NFKB2;BCL2;PIK3CB;PPP2R1A;MAPK8;BCL2L1;MAPK3;TSC2;

ITGA1;KRAS;EIF4EBP1;RELA;PRKCD;NOS3;PRKAA1;MAPK9;CDK2;PPP2CA;PIM1;ITGB7;

YWHAZ;ILK;TP53;RAF1;IKBKG;RELB;DYRK1A;CDKN1A;ITGB1;MAP2K2;JAK1;AKT1;JAK2;PIK3R1;

CHUK;PDPK1;PPP2R5C;CTNNB1;MAP2K1;NFKB1;PAK3;ITGB3;CCND1;GSK3A;FRAP1;SFN;ITGA2;

TTK;CSNK1A1;BRAF;GSK3B;AKT3;FOXO1;SGK;HSP90AA1;RPS6KB1

ERK/MAPK signaling

PRKCE;ITGAM;ITGA5;HSPB1;IRAK1;PRKAA2;EIF2AK2;RAC1;RAP1A;TLN1;EIF4E;ELK1;GRK6;

MAPK1;RAC2;PLK1;AKT2;PIK3CA;CDK8;CREB1;PRKCI;PTK2;FOS;RPS6KA4;PIK3CB;PPP2R1A;

PIK3C3;MAPK8;MAPK3;ITGA1;ETS1;KRAS;MYCN;EIF4EBP1;PPARG;PRKCD;PRKAA1;MAPK9;SRC;

CDK2;PPP2CA;PIM1;PIK3C2A;ITGB7;YWHAZ;PPP1CC;KSR1;PXN;RAF1;FYN;DYRK1A;ITGB1;

MAP2K2;PAK4;PIK3R1;STAT3;PPP2R5C;MAP2K1;PAK3;ITGB3;ESR1;ITGA2;MYC;TTK;CSNK1A1;

CRKL;BRAF;ATF4;PRKCA;SRF;STAT1;SGK

Glucocorticoid   receptor signaling

RAC1;TAF4B;EP300;SMAD2;TRAF6;PCAF;ELK1;MAPK1;SMAD3;AKT2;IKBKB;NCOR2;UBE2I;

PIK3CA;CREB1;FOS;HSPA5;NFKB2;BCL2;MAP3K14;STAT5B;PIK3CB;PIK3C3;MAPK8;BCL2L1;

MAPK3;TSC22D3;MAPK10;NRIP1;KRAS;MAPK13;RELA;STAT5A;MAPK9;NOS2A;PBX1;NR3C1;

PIK3C2A;CDKN1C;TRAF2;SERPINE1;NCOA3;MAPK14;TNF;RAF1;IKBKG;MAP3K7;CREBBP;

CDKN1A;MAP2K2;JAK1;IL8;NCOA2;AKT1;JAK2;PIK3R1;CHUK;STAT3;MAP2K1;NFKB1;TGFBR1;

ESR1;SMAD4;CEBPB;JUN;AR;AKT3;CCL2;MMP1;STAT1;IL6;HSP90AA1

Axon-directed   signaling

PRKCE;ITGAM;ROCK1;ITGA5;CXCR4;ADAM12;IGF1;RAC1;RAP1A;EIF4E;PRKCZ;NRP1;NTRK2;

ARHGEF7;SMO;ROCK2;MAPK1;PGF;RAC2;PTPN11;GNAS;AKT2;PIK3CA;ERBB2;PRKCI;PTK2;

CFL1;GNAQ;PIK3CB;CXCL12;PIK3C3;WNT11;PRKD1;GNB2L1;ABL1;MAPK3;ITGA1;KRAS;RHOA;

PRKCD;PIK3C2A;ITGB7;GLI2;PXN;VASP;RAF1;FYN;ITGB1;MAP2K2;PAK4;ADAM17;AKT1;PIK3R1;

GLI1;WNT5A;   ADAM10;MAP2K1;PAK3;ITGB3;CDC42;VEGFA;ITGA2;EPHA8;CRKL;RND1;GSK3B;AKT3;PRKCA

Ephrin receptor   signaling

PRKCE;ITGAM;ROCK1;ITGA5;CXCR4;IRAK1;PRKAA2;EIF2AK2;RAC1;RAP1A;GRK6;ROCK2;

MAPK1;   PGF;RAC2;PTPN11;GNAS;PLK1;AKT2;DOK1;CDK8;CREB1;PTK2;CFL1;GNAQ;MAP3K14;

CXCL12;MAPK8;GNB2L1;ABL1;MAPK3;ITGA1;KRAS;KHOA;PRKCD;PRKAA1;MAPK9;SRC;CDK2;

PIM1;ITGB7;PXN;RAF1;FYN;DYRK1A;ITGB1;MAP2K2;PAK4;AKT1;JAK2;STAT3;ADAM10;

MAP2K1;PAK3;ITGB3;CDC42;VEGFA;ITGA2;EPHA8;TTK;CSNK1A1;CRKL;BRAF;PTPN13;ATF4;AKT3;SGK

Actin   cytoskeleton signaling

PRKAA2;EIF2AK2;RAC1;INS;ARHGEF7;GRK6;ROCK2;MAPK1;RAC2;PLK1;AKT2;PIK3CA;CDK8;

PTK2;CFL1;PIK3CB;MYH9;DIAPH1;PIK3C3;MAPK8;F2R;MAPK3;SLC9A1;ITGA1;KRAS;RHOA;PRKCD;

PRKAA1;MAPK9;CDK2;PIM1;PIK3C2A;ITGB7;PPP1CC;PXN;VIL2;RAF1;GSN;DYRK1A;ITGB1;

MAP2K2;PAK4;PIP5K1A;PIK3R1;MAP2K1;PAK3;ITGB3;CDC42;APC;ITGA2;TTK;CSNK1A1;CRKL;BRAF;VAV3;SGK

Huntington's   disease signaling

PRKCE;IGF1;EP300;RCOR1;PRKCZ;HDAC4;TGM2;MAPK1;CAPNS1;AKT2;EGFR;NCOR2;SP1;CAPN2;

PIK3CA;HDAC5;CREB1;PRKCI;HSPA5;REST;GNAQ;PIK3CB;PIK3C3;MAPK8;IGF1R;PRKD1;

GNB2L1;BCL2L1;CAPN1;MAPK3;CASP8;HDAC2;HDAC7A;PRKCD;HDAC11;MAPK9;HDAC9;PIK3C2A;

HDAC3;TP53;CASP9;CREBBP;AKT1;PIK3R1;PDPK1;CASP1;APAF1;FRAP1;CASP2;JUN;BAX;

ATF4;AKT3;PRKCA;CLTC;SGK;HDAC6;CASP3

Apoptosis   signaling

PRKCE;ROCK1;BID;IRAK1;PRKAA2;EIF2AK2;BAK1;BIRC4;GRK6;MAPK1;CAPNS1;PLK1;AKT2;IKBKB;

CAPN2;CDK8;FAS;NFKB2;BCL2;MAP3K14;MAPK8;BCL2L1;CAPN1;MAPK3;CASP8;KRAS;RELA;

PRKCD;PRKAA1;MAPK9;CDK2;PIM1;TP53;TNF;RAF1;IKBKG;RELB;CASP9;DYRK1A;MAP2K2;CHUK;APAF1;

MAP2K1;NFKB1;PAK3;LMNA;CASP2;BIRC2;TTK;CSNK1A1;BRAF;BAX;PRKCA;SGK;CASP3;BIRC3;PARP1

B cell receptor signaling

RAC1;PTEN;LYN;ELK1;MAPK1;RAC2;PTPN11;AKT2;IKBKB;PIK3CA;CREB1;SYK;NFKB2;CAMK2A;

MAP3K14;PIK3CB;PIK3C3;MAPK8;BCL2L1;ABL1;MAPK3;ETS1;KRAS;MAPK13;RELA;PTPN6;MAPK9;

EGR1;PIK3C2A;BTK;MAPK14;RAF1;IKBKG;RELB;MAP3K7;MAP2K2;AKT1;PIK3R1;CHUK;MAP2K1;

NFKB1;CDC42;GSK3A;FRAP1;BCL6;BCL10;JUN;GSK3B;ATF4;AKT3;VAV3;RPS6KB1

Leukocyte   extravasation signaling

ACTN4;CD44;PRKCE;ITGAM;ROCK1;CXCR4;CYBA;RAC1;RAP1A;PRKCZ;ROCK2;RAC2;PTPN11;

MMP14;PIK3CA;PRKCI;PTK2;PIK3CB;CXCL12;PIK3C3;MAPK8;PRKD1;ABL1;MAPK10;CYBB;

MAPK13;RHOA;PRKCD;MAPK9;SRC;PIK3C2A;BTK;MAPK14;NOX1;PXN;VIL2;VASP;ITGB1;MAPK2K2;

CTNND1;PIK3R1;CTNNB1;CLDN1;CDC42;F11R;ITK;CRKL;VAV3;CTTN;PRKCA;MMP1;MMP9

Integrin   signaling

ACTN4;ITGAM;ROCK1;ITGA5;RAC1;PTEN;PAP1A;TLN1;ARHGEF7;MAPK1;RAC2;CAPNS1;AKT2;

CAPN2;PIK3CA;PTK2;PIK3CB;PIK3C3;MAPK8;CAV1;CAPN1;ABL1;MAPK3;ITGA1;KRAS;RHOA;

SRC;PIK3C2A;ITGB7;PPP1CC;ILK;PXN;VASP;RAF1;FYN;ITGB1;MAP2K2;PAK4;AKT1;PIK3R1;

TNK2;MAP2K1;PAK3;ITGB3;CDC42;RND3;ITGA2;CRKL;BRAF;GSK3B;AKT3

Acute phase   response signaling

IRAK1;SOD2;MYD88;TRAF6;ELK1;MAPK1;PTPN11;AKT2;IKBKB;PIK3CA;FOS;NFKB2;MAP3K14;

PIK3CB;MAPK8;RIPK1;MAPK3;IL6ST;KRAS;MAPK13;IL6R;RELA;SOCS1;MAPK9;FTL;NR3C1;

TRAF2;SERPINE1;MAPK14;TNF;RAF1;PDK1;IKBKG;RELB;MAP3K7;MAP2K2;AKT1;JAK2;PIK3R1;

CHUK;STAT3;MAP2K1;NFKB1;FRAP1;CEBPB;JUN;AKT3;IL1R1;IL6

PTEN signaling

ITGAM;ITGA5;RAC1;PTEN;PRKCZ;BCL2L11;MAPK1;RAC2;AKT2;EGFR;IKBKB;CBL;PIK3CA;

CDKN1B;PTK2;NFKB2;BCL2;PIK3CB;BCL2L1;MAPK3;ITGA1;KRAS;ITGB7;ILK;PDGFRB;INSR;

RAF1;IKBKG;CASP9;CDKN1A;ITGB1;MAP2K2;AKT1;PIK3R1;CHUK;PDGFRA;PDRK1;MAP2K1;

NFKB1;ITGB3;CDC42;CCND1;GSK3A;ITGA2;GSK3B;AKT3;FOXO1;CASP3;RPS6KB1

p53 signaling

PTEN;EP300;BBC3;PCAF;FASN;BRCA1;GADD45A;BIRC5;AKT2;PIK3CA;CHEK1;TP53INP1;BCL2;

PIK3CB;PIK3C3;MAPK8;THBS1;ATR;BCL2L1;E2F1;PMAIP1;CHEK2;TNFRSF10B;TP73;RB1;HDAC9;

CDK2;PIK3C2A;MAPK14;TP53;LRDD;CDKN1A;HIPK2;AKT1;PIK3R1;RRM2B;APAF1;CTNNB1;

SIRT1;CCND1;PRKDC;ATM;SFN;CDKN2A;JUN;SNAI2;GSK3B;BAX;AKT3

Aryl hydrocarbon   receptor signaling

HSPB1;EP300;FASN;TGM2;RXRA;MAPK1;NQO1;NCOR2;SP1;ARNT;CDKN1B;FOS;CHEK1;

SMARCA4;NFKB2;MAPK8;ALDH1A1;ATR;E2F1;MAPK3;NRIP1;CHEK2;RELA;TP73;GSTP1;RB1;

SRC;CDK2;AHR;NFE2L2;NCOA3;TP53;TNF;CDKN1A;NCOA2;APAF1;NFKB1;CCND1;ATM;ESR1;

CDKN2A;MYC;JUN;ESR2;BAX;IL6;CYP1B1;HSP90AA1

Xenobiotic   metabolism signaling

PRKCE;EP300;PRKCZ;RXRA;MAPK1;NQO1;NCOR2;PIK3CA;ARNT;PRKCI;NFKB2;CAM2A;

PIK3CB;PPP2R1A;PIK3C3;MAPK8;PRKD1;ALDH1A1;MAPK3;NRIP1;KRAS;MAPK13;PRKCD;

GSTP1;MAPK9;NOS2A;ABCB1;AHR;PPP2CA;FTL;NFE2L2;PIK3C2A;PPARGC1A;MAPK14;TNF;RAF1;

CREBBP;MAP2K2;PIK3R1;PPP2R5C;MAP2K1;NFKB1;KEAP1;PRKCA;EIF2AK3;IL6;CYP1B1;HSP90AA1

SAPK/JNK signaling

PRKCE;IRAK1;PRKAA2;EIF2AK2;RAC1;ELK1;GRK6;MAPK1;GADD45A;RAC2;PLK1;AKT2;PIK3CA;

FADD;CDK8;PIK3CB;PIK3C3;MAPK8;RIPK1;GNB2L1;IRS1;MAPK3;MAPK10;DAXX;KRAS;

PRKCD;PRKAA1;MAPK9;CDK2;PIM1;PIK3C2A;TRAF2;TP53;LCK;MAP3K7;DYRK1A;MAP2K2;

PIK3R1;MAP2K1;PAK3;CDC42;JUN;TTK;CSNK1A1;CRKL;BRAF;SGK

PPAr/RXR signaling

PRKAA2;EP300;INS;SMAD2;TRAF6;PPARA;FASN;RXRA;MAPK1;SMAD3;GNAS;IKBKB;KCOR2;

ABCA1;GNAQ;NFKB2;MAP3K14;STAT5B;MAPK8;IRS1;MAPK3;KRAS;RELA;PRKAA1;PPARGC1A;

NCOA3;MAPK14;INSR;RAF1;IKBKG;RELB;MAP3K7;CREBBP;MAP2K2;JAK2;CHUK;MAP2K1;NFKB1;

TGFBR1;SMAD4;JUN;IL1R1;PRKCA;IL6;HSP90AA1;ADIPOQ

NF-KB signaling

IRAK1;EIF2AK2;EP300;INS;MYD88;PRKCZ;TRAF6;TBK1;AKT2;EGFR;IKBKB;PIK3CA;PTRC;NFKB2;

MAP3K14;PIK3CB;PIK3C3;MAPK8;RIPK1;HDAC2;KRAS;RELA;PIK3C2A;TRAF2;TLR4;PDGFRB;TNF;   INSR;LCK;

IKBKG;RELB;MAP3K7;CREBBP;AKT1;PIK3R1;CHUK;PDGFRA;NFKB1;TLR2;BCL10;GSK3B;AKT3;TNFAIP3;IL1R1

Neuregulin   signaling

ERBB4;PRKCE;ITGAM;ITGA5;PTEN;PRKCZ;ELK1;MAPK1;PTPN11;AKT2;EGFR;ERBB2;PRKCI;

CDKN1B;STAT5B;PRKD1;MAPK3;ITGA1;KRAS;PRKCD;STAT5A;SRC;ITGB7;RAF1;ITGB1;MAP2K2;

ADAM17;AKT1;PIK3R1;PDPK1;MAP2K1;ITGB3;EREG;ERAP1;PSEN1;ITGA2;MYC;NRG1;CRKL;

AKT3;PRKCA;HSP90AA1;RPS6KB1

Wnt/ β-Catenin signaling

CD44;EP300;LRP6;DVL3;CSNK1E;GJA1;SMO;AKT2;PIN1;CDH1;BTRC;GNAQ;MARK2;PPP2R1A;

WNT11;SRC;DKK1;PPP2CA;SOX6;SFRP2;ILK;LEF1;SOX9;TP53;MAP3K7;CREBBP;TCF7L2;AKT1;PPP2R5C;

WNT5A;LRP5;CTNNB1;TGFBR1;CCND1;GSK3A;DVL1;APC;CDKN2A;MYC;CSNK1A1;GSK3B;AKT3;SOX2

Insulin receptor   signaling

PTEN;INS;EIF4E;PTPN1;PRKCZ;MAPK1;TSC1;PTPN11;AKT2;CBL;PIK3CA;PRKCI;PIK3CB;PIK3C3;

MAPK8;IRS1;MAPK3;TSC2;KRAS;EIF4EBP1;SLC2A4;PIK3C2A;PPP1CC;INSR;RAF1;FYN;

MAP2K2;JAK1;AKT1;JAK2;PIK3R1;PDPK1;MAP2K1;GSK3A;FRAP1;CRKL;GSK3B;AKT3;FOXO1;SGK;RPS6KB1

IL-6 signaling

HSPB1;TRAF6;MAPKAPK2;ELK1;MAPK1;PTPN11;IKBKB;FOS;NFKB2;MAP3K14;MAPK8;MAPK3;

MAPK10;IL6ST;KRAS;MAPK13;IL6R;RELA;SOCS1;MAPK9;ABCB1;TRAF2;MAPK14;TNF;RAF1;IKBKG;

RELB;MAP3K7;MAP2K2;IL8;JAK2;CHUK;STAT3;MAP2K1;NFKB1;CEBPB;JUN;IL1R1;SRF;IL6

Hepatic   cholestasis

PRKCE;IRAK1;INS;MYD88;PRKCZ;TRAF6;PPARA;RXRA;IKBKB;PRKCI;NFKB2;MAP3K14;MAPK8;

PRKD1;MAPK10;RELA;PRKCD;MAPK9;ABCB1;TRAF2;TLR4;TNF;INSR;IKBKG;RELB;MAP3K7;IL8;

CHUK;NR1H2;TJP2;NFKB1;ESR1;SREBF1;FGFR4;JUN;IL1R1;PRKCA;IL6

IGF-1 signaling

IGF1;PRKCZ;ELK1;MAPK1;PTPN11;NEDD4;AKT2;PIK3CA;PRKCI;PTK2;FOS;PIK3CB;PIK3C3;MAPK8;

IGF1R;IRS1;MAPK3;IGFBP7;KRAS;PIK3C2A;YWHAZ;PXN;RAF1;CASP9;MAP2K2;AKT1;PIK3R1;

PDPK1;MAP2K1;IGFBP2;SFN;JUN;CYR61;AKT3;FOXO1;SRF;CTGF;RPS6KB1

NRF2-mediated   oxidative stress response

PRKCE;EP300;SOD2;PRKCZ;MAPK1;SQSTM1;NQO1;PIK3CA;PRKCI;FOS;PIK3CB;PIK3C3;MAPK8;

PRKD1;MAPK3;KRAS;PRKCD;GSTP1;MAPK9;FTL;NFE2L2;PIK3C2A;MAPK14;RAF1;MAP3K7;CREBBP;

MAP2K2;AKT1;PIK3R1;MAP2K1;PPIB;JUN;KEAP1;GSK3B;ATF4;PRKCA;EIF2AK3;HSP90AA1

Liver   fibrosis/hepatic stellate cell activation

SMAD3;EGFR;FAS;CSF1;NFKB2;BCL2;MYH9;IGF1R;IL6R;RELA;TLR4;PDGFRB;TNF;RELB;IL8;

PDGFRA;NFKB1;TGFBR1;SMAD4;VEGFA;BAX;IL1R1;CCL2;HGF;MMP1;STAT1;IL6;CTGF;MMP9

PPAR signaling

EP300;INS;TRAF6;PPARA;RARA;MAPK1;IKBKB;NCOR2;FOS;NFKB2;MAP3K14;STAT5B;MAPK3;

NRIP1;KRAS;PPARG;RELA;STAT5A;TRAF2;PPARGC1A;PDGFRB;TNF;INSR;RAF1;IKBKG;

RELB;MAP3K7;CREBBP;MAP2K2;CHUK;PDGFRA;MAP2K1;NFKB1;JUN;IL1R1;HSP90AA1

Fc epsilon RI   signaling

PRKCE;RAC1;PRKCZ;LYN;MAPK1;RAC2;PTPN11;AKT2;PIK3CA;SYK;PRKCI;PIK3CB;PIK3C3;MAPK8;

PRKD1;MAPK3;MAPK10;KRAS;MAPK13;PRKCD;MAPK9;PIK3C2A;BTK;MAPK14;TNF;RAF1;FYN;

MAP2K2;AKT1;RIK3R1;PDPK1;MAP2K1;AKT3;VAV3;PRKCA

G-protein   coupled receptor signaling

PRKCE;RAP1A;RGS16;MAPK1;GNAS;AKT2;IKBKB;PIK3CA;CREB1;GNAQ;NFKB2;CAMK2A;PIK3CB;

PIK3C3;MAPK3;KRAS;RELA;SRC;PIK3C2A;RAF1;IKBKG;RELB;FYN;MAP2K2;AKT1;PIK3R1;CHUK;

PDPK1;STAT3;MAP2K1;NFKB1;BRAF;ATF4;AKT3;PRKCA

Phosphoinositide   metabolism

PRKCE;IRAK1;PRKAA2;EIF2AK2;PTEN;GRK6;MAPK1;PLK1;AKT2;PIK3CA;CDK8;PIK3CB;PIK3C3;

MAPK8;MAPK3;PRKCD;PRKAA1;MAPK9;CDK2;PIM1;PIK3C2A;DYRKIA;MAP2K2;PIP5K1A;PIK3R1;

MAP2K1;PAK3;ATM;TTK;CSNK1A1;BRAF;SGK

PDGF signaling

EIF2AK2;ELK1;ABL2;MAPK1;PIK3CA;FOS;PIK3CB;PIK3C3;MAPK8;CAV1;ABL1;MAPK3;KRAS;SRC;

PIK3C2A;PDGFRB;RAF1;MAP2K2;JAK1;JAK2;PIK3R1;PDGFRA;STAT3;SPHK1;MAP2K1;MYC

JUN;CRKL;PRKCA;SRF;STAT1;SPHK2

VEGF signaling

ACTN4;ROCK1;KDR;FLT1;ROCK2;MAPK1;PGF;AKT2;PIK3CA;ARNT;PTK2;BCL2;PIK3CB;PIK3C3;   BCL2L1;MAPK3;

KRAS;HIF1A;NOS3;PIK3C2A;PXN;RAF1;MAP2K2;ELAVL1;AKT1;PIK3R1;MAP2K1;SFN;VEGFA;AKT3;FOXO1;PRKCA

Natural killer   cell signaling

PRKCE;RAC1;PRKCZ;MAPK1;RAC2;PTPN11;KIR2DL3;AKT2;PIK3CA;SYK;PRKCI;PIK3CB;

PIK3C3;PRKD1;MAPK3;KRAS;PRKCD;PTPN6;PIK3C2A;LCK;RAF1;FYN;MAP2K2;PAK4;AKT1;

PIK3R1;MAP2K1;PAK3;AKT3;VAV3;PRKCA

Cell cycle G1/S   checkpoint regulation

HDAC4;SMAD3;SUV39H1;HDAC5;CDKN1B;BTRC;ATR;ABL1;E2F1;HDAC2;HDAC7A;RB1;HDAC11;HDAC9;CDK2;

E2F2;HDAC3;TP53;CDKN1A;CCND1;E2F4;ATM;RBL2;SMAD4;CDKN2A;MYC;NRG1;GSK3B;RBL1;HDAC6

T cell receptor signaling

RAC1;ELK1;MAPK1;IKBKB;CBL;PIK3CA;FOS;NFKB2;PIK3CB;PIK3C3;MAPK8;MAPK3;KRAS;

RELA;PIK3C2A;BTK;LCK;RAF1;IKBKG;RELB;FYN;MAP2K2;PIK3R1;CHUK;MAP2K1;NFKB1;ITK;BCL10;JUN;VAV3

Death receptor signaling

CRADD;HSPB1;BID;BIRC4;TBK1;IKBKB;FADD;FAS;NFKB2;BCL2;MAP3K14;MAPK8;RIPK1;CASP8;

DAXX;TNFRSF10B;RELA;TRAF2;TNF;IKBKG;RELB;CASP9;CHUK;APAF1;NFKB1;CASP2;BIRC2;CASP3;BIRC3

FGF signaling

RAC1;FGFR1;MET;MAPKAPK2;MAPK1;PTPN11;AKT2;PIK3CA;CREB1;PIK3CB;PIK3C3;MAPK8;MAPK3;MAPK13;

PTPN6;PIK3C2A;MAPK14;RAF1;AKT1;PIK3R1;STAT3;MAP2K1;FGFR4;CRKL;ATF4;AKT3;PRKCA;HGF

GM-CSF signaling

LYN;ELK1;MAPK1;PTPN11;AKT2;PIK3CA;CAMK2A;STAT5B;PIK3CB;PIK3C3;GNB2L1;BCL2L1;MAPK3;

ETS1;KRAS;RUNX1;RIM1;PIK3C2A;RAF1;MAP2K2;AKT1;JAK2;PIK3R1;STAT3;MAP2K1;CCND1;AKTS;STAT1

Amyotrophic   lateral sclerosis signaling

BID;IGF1;RAC1;BIRC4;PGF;CAPNS1;CAPN2;PIK3CA;BCL2;PIK3CB;PIK3C3;BCL2L1;CAPN1;

PIK3C2A;TP53;CASP9;PIK3R1;RAB5A;CASP1;APAF1;VEGFA;BIRC2;BAX;AKT3;CASP3;BIRC3

JAK/Stat signaling

PTPN1;MAPK1;PTPN11;AKT2;PIK3CA;STAT5B;PIK3CB;PIK3C3;MAPK3;KRAS;SOCS1;STAT5A;

PTPN6;PIK3C2A;RAF1;CDKN1A;MAP2K2;JAK1;AKT1;JAK2;PIK3R1;STAT3;MAP2K1;FRAP1;AKT3;STAT1

Niacin and   Niacinamide metabolism

PRKCE;IRAK1;PRKAA2;EIF2AK2;GRK6;MAPK1;PLK1;AKT2;CDK8;MAPK8;MAPK3;PRKCD;PRKAA1;

PBEF1;MAPK9;CDK2;PIM1;DYRK1A;MAP2K2;MAP2K1;PAK3;NT5E;TTK;CSNK1A1;BRAF;SGK

Chemokine   signaling

CXCR4;ROCK2;MAPK1;PTK2;FOS;CFL1;GNAQ;CAMK2A;CXCL12;MAPK8;MAPK3;KRAS;MAPK13;

RHOA;CCR3;SRC;PPP1CC;MAPK14;NOX1;RAF1;MAP2K2;MAP2K1;JUN;CCL2;PRKCA

IL-2 signaling

ELK1;MAPK1;PTPN11;AKT2;PIK3CA;SYK;FOS;STAT5B;PIK3CB;PIK3C3;MAPK8;MAPK3;KRAS;

SOCS1;STAT5A;PIK3C2A;LCK;RAF1;MAP2K2;JAK1;AKT1;PIK3R1;MAP2K1;JUN;AKT3

Long-term   synaptic depression

PRKCE;IGF1;PRKCZ;PRDX6;LYN;MAPK1;GNAS;PRKCI;GNAQ;PPP2R1A;IGF1R;PRKD1;MAPK3;

KRAS;GRN;PRKCD;NOS3;NOS2A;PPP2CA;YWHAZ;RAF1;MAP2K2;PPP2R5C;MAP2K1;PRKCA

Estrogen   receptor signaling

TAF4B;EP300;CARM1;PCAF;MAPK1;NCOR2;SMARCA4;MAPK3;NRIP1;KRAS;SRC;NR3C1;

HDAC3;PPARGC1A;RBM9;NCOA3;RAF1;CREBBP;MAP2K2;NCOA2;MAP2K1;PRKDC;ESR1;ESR2

Protein   ubiquitination pathway

TRAF6;SMURF1;BIRC4;BRCA1;UCHL1;NEDD4;CBL;UBE2I;BTRC;HSPA5;USP7;USP10;FBXW7;

USP9X;STUB1;USP22;B2M;BIRC2;PARK2;USP8;USP1;VHL;HSP90AA1;BIRC3

IL-10 signaling

TRAF6;CCR1;ELK1;IKBKB;SP1;FOS;NFKB2;MAP3K14;MAPK8;MAPK13;RELA;MAPK14;TNF;

IKBKG;RELB;MAP3K7;JAK1;CHUK;STAT3;NFKB1;JUN;IL1R1;IL6

VDR/RXR   activation

PRKCE;EP300;PRKCZ;RXRA;GADD45A;HES1;NCOR2;SP1;PRKCI;CDKN1B;PRKD1;PRKCD;

RUNX2;KLF4;YY1;NCOA3;CDKN1A;NCOA2;SPP1;LRP5;CEBPB;FOXO1;RPKCA

TGF-βsignaling

EP300;SMAD2;SMURF1;MAPK1;SMAD3;SMAD1;FOS;MAPK8;MAPK3;KRAS;MAPK9;RUNX2;

SERPINE1;RAF1;MAP3K7;CREBBP;MAP2K2;MAP2K1;TGFBR1;SMAD4;JUN;SMAD5

Toll like   receptor signaling

IRAK1;EIF2AK2;MYD88;TRAF6;PPARA;ELK1;IKBKB;FOS;NFKB2;MAP3K14;MAPK8;MAPK13;

RELA;TLR4;MAPK14;IKBKG;RELB;MAP3K7;CHUK;NFKB1;TLR2;JUN

p38 MAPK signaling

HSPB1;IRAK1;TRAF6;MAPKAPK2;ELK1;FADD;FAS;CREB1;DDIT3;RPS6KA4;DAXX;MAPK13;TRAF2;

MAPK14;TNF;MAP3K7;TGFBR1;MYC;ATF4;IL1R1;SRF;STAT1

Neurotrophin/TRK   signaling

NTRK2;MAPK1;PTPN11;PIK3CA;CREB1;FOS;PIK3CB;PIK3C3;MAPK8;MAPK3;KRAS;PIK3C2A;

RAF1;MAP2K2;AKT1;PIK3R1;PDPK1;MAP2K1;CDC42;JUN;ATF4

FXR/RXR activation

INS;PPARA;FASN;RXRA;AKT2;SDC1;MAPK8;APOB;MAPK10;PPARG;MTTP;MAPK9;PPARGC1A;

TNF;CREBBP;AKT1;SREBF1;FGFR4;AKT3;FOXO1

Synaptic   long-term potentiation

PRKCE;RAP1A;EP300;PRKCZ;MAPK1;CREB1;PRKCI;GNAQ;CAMK2A;PRKD1;MAPK3;KRAS

PRKCD;PPP1CC;RAF1;CREBBP;MAP2K2;MAP2K1;ATF4;PRKCA

Calcium signaling

RAP1A;EP300;HDAC4;MAPK1;HDAC5;CREB1;CAMK2A;MYH9;MAPK3;HDAC2;HDAC7A;HDAC11;

HDAC9;HDAC3;CREBBP;CALR;CAMKK2;ATF4;HDAC6

EGF signaling

ELK1;MAPK1;EGFR;PIK3CA;FOS;PIK3CB;PIK3C3;MAPK8;MAPK3;PIK3C2A;RAF1;JAK1;PIK3R1;   STAT3;MAP2K1;JUN;PRKCA;SRF;STAT1

Hypoxic   signaling in the cardiovascular system

EDN1;PTEN;EP300;NQO1;UBE2I;CREB1;ARNT;HIF1A;SLC2A;NOS3;TP53;LDHA;AKT1;ATM;  

VEGFA;JUN;ATF4;VHL;HSP90AA1

LPS/IL-1-mediated   inhibition of RXR function

IRAK1;MYD88;TRAF6;PPARA;RXRA;ABCA1;MAPK8;ALDH1A1;GSTP1;MAPK9;ABCB1;TRAF2;  

TLR4;TNF;MAP3K7;NR1H2;SREBF1;JUN;IL1R1

LXR/RXR activation

FASN;RXRA;NCOR2;ABCA1;NFKB2;IRF3;RELA;NOS2A;TLR4;TNF;RELB;LDLR;NR1H2;NFKB1;   SREBF1;IL1R1;CCL2;IL6;MMP9

Amyloid   processing

PRKCE;CSNK1E;MAPK1;CAPNS1;AKT2;CAPN2;CAPN1;MAPK3;MAPK13;MAPT;MAPK14;AKT1;   PSEN1;CSNK1A1;GSK3B;AKT3;APP

IL-4 signaling

AKT2;PIK3CA;PIK3CB;PIK3C3;IRS1;KRAS;SOCS1;PTPN6;NR3C1;PIK3C2A;JAK1;AKT1;JAK2;PIK3R1;   FRAP1;AKT3;RPS6KB1

Cell cycle: G2/M   DNA damage checkpoint regulation

EP300;PCAF;BRCA1;GADD45A;PLK1;BTRC;CHEK1;ATR;CHEK2;YWHAZ;TP53;CDKN1A;PRKDC;ATM;SFN;CDKN2A

Nitric oxide   signaling in the cardiovascular system

KDR;FLT1;PGF;AKT2;PIK3CA;PIK3CB;PIK3C3;CAV1;PRKCD;NOS3;PIK3C2A;AKT1;PIK3R1;

VEGFA;AKT3;HSP90AA1

Purine   metabolism

NME2;SMARCA4;MYH9;RRM2;ADAR;EIF2AK4;PKM2;ENTPD1;RAD51;RRM2B;TJP2;RAD51C;NT5E;POLD1;NME1

cAMP -mediated signaling

RAP1A;MAPK1;GNAS;CREB1;CAMK2A;MAPK3;SRC;RAF1;MAP2K2;STAT3;MAP2K1;BRAF;ATF4

Mitochondrial   dysfunction

SOD2;MAPK8;CASP8;MAPK10;MAPK9;CASP9;PARK7;PSEN1;PARK2;APP;CASP3

Notch signaling

HES1;JAG1;NUMB;NOTCH4;ADAM17;NOTCH2;PSEN1;NOTCH3;NOTCH1;DLL4

Endoplasmic   reticulum stress pathway

HSPA5;MAPK8;XBP1;TRAF2;ATF6;CASP9;ATF4;EIF2AK3;CASP3

Pyrimidine   metabolism

NME2;AICDA;RRM2;EIF2AK4;ENTPD1;RRM2B;NT5E;POLD1;NME1

Parkinson's   Disease signaling

UCHL1;MAPK8;MAPK13;MAPK14;CASP9;PARK7;PARK2;CASP3

Cardiac &   Beta Adrenergic Signaling

GNAS;GNAQ;PPP2R1A;GNB2L1;PPP2CA;PPP1CC;PPP2R5C

Glycolysis/gluconeogenesis

HK2;GCK;GPI;ALDH1A1;PKM2;LDHA;HK1

Interferon signaling

IRF1;SOCS1;JAK1;JAK2;IFITM1;STAT1;IFIT3

Sonic hedgehog signaling

ARRB2;SMO;GLI2;DYRK1A;GLI1;GSK3B;DYRK1B

Glycerophospholipid   metabolism

PLD1;GRN;GPAM;YWHAZ;SPHK1;SPHK2

Phospholipid   degradation

PRKX6;PLD1;GRN;YWHAZ;SPHK1;SPHK2

Tryptophan   metabolism

SIAH2;PRMT5;NEDD4;ALDH1A1;CYP1B1;SIAH1

Lysine   metabolism

SUV39H1;EHMT2;NSD1;SETD7;PPP2R5C

Nucleotide   excision repair pathway

ERCC5;ERCC4;XPA;XPC;ERCC1

Starch and   sucrose metabolism

UCHL1;HK2;GCK;GPI;HK1

Amino sugar   metabolism

NQO1;HK2;GCK;HK1

Arachidonic acid   metabolism

PPDX6;GRN;YWHAZ;CYP1B1

Circadian rhythm   signaling

CSNK1E;CREB1;ATF4;NR1D1

Coagulation   system

BDKRB1;F2R;SEPPINE1;F3

Dopamine   receptor signaling

PPP2R1A;PPP2CA;PPP1CC;PPP2R5C

Glutathione metabolism

IDH2;GSTP1;ANPEP;IDH1

Glycerolipid   metabolism

ALDH1A1;GPAM;SPHK1;SPHK2

Linoleic acid   metabolism

PRDX6;GRN;YWHAZ;CYP1B1

Methionine   metabolism

DNMT1;DNMT3B;AHCY;DNMT3A

Pyruvate   metabolism

GLO1;ALDH1A1;PKM2;LDHA

Arginine and   proline metabolism

ALDH1A1;NOS3;NOS2A

Eicosanoid   signaling

PRDX6;GRN;YWHAZ

Fructose and   Mannose Metabolism

HK2;GCK;HK1

Galactose   metabolism

HK2;GCK;HK1

Stilbene,   coumarin and lignin biosynthesis

PRDX6;PRDX1;TYR

Antigen   presentation pathway

CALR;B2M

Steroid   biosynthesis

NQO1;DHCR7

Butyrate   metabolism

ALDH1A1;NLGN1

Citric acid   cycle

IDH2;IDH1

Fatty acid   metabolism

ALDH1A1;CYP1B1

Glycerophospholipid   metabolism

PRDX6;CHKA

Histidine   metabolism

PRMT5;ALDH1A1

Inositol   metabolism

ERO1L;APEX1

Metabolism of   foreign substances by cytochrome p450

GSTP1;CYP1B1

Methane   metabolism

PRDX6;PRDX1

Phenylalanine   metabolism

PRDX6;PRDX1

Propionic acid   metabolism

ALDH1A1;LDHA

Selenium-containing   amino acid metabolism

PRMT5;AHCY

Sphingolipid   metabolism

SPHK1;SPHK2

Aminophosphonic   acid metabolism

PRMT5

Androgen and   estrogen metabolism

PRMT5

Ascorbic acid   and Aldarate metabolism

ALDH1A1

Bile acid   biosynthesis

ALDH1A1

Cysteine   metabolism

LDHA

Fatty acid   biosynthesis

FASN

Glutamate   receptor signaling

GNB2L1

NRF2-mediated oxidative   stress

PRDX1

Pentose   Phosphate Pathway

GPI

Interconversion   of pentose and glucuronic acid

UCHL1

Retinol   metabolism

ALDH1A1

Riboflavin   metabolism

TYR

Tyrosine   metabolism

PRMT5,TYR

Ubiquinone   biosynthesis

PRMT5

Valine, Leucine   and Isoleucine Degradation

ALDH1A1

Glycine, serine   and threonine metabolism

CHKA

Lysine   degradation

ALDH1A1

Pain/Taste

TRPM5;TRPA1

Pain

TRPM7;TRPC5;TRPC6;TRPC1;Cnrl;cnr2;Grk2;Trpal;Pomc;Cgrp;Crf;Pka;Era;Nr2b;TRPM5;Prkaca;Prkacb;Prkarla;Prkar2a

Mitochondrial   function

AIF;CytC;SMAC(Diablo);Aifm-1;Aifm-2

Developmental   Neurology

WNT(Wnt2; Wnt2b;   Wnt3b; Wnt4; Wnt5a; Wnt6; Wnt7b; Wnt8b; Wnt9a; Wnt9b; Wnt10a; Wnt10b; Wnt16);

BMP-3;Chordin   (Chrd);Nog;β-catenin;Dkk-1; frizzled-associated   protein;Otx-2;Gbx2;EGF-8;

Reelin;Dab1;unc-86(Pou4f1   or Brn3a);Numb;Reln